Special Considerations and Clinical Management of HIV-Infected Drug Users
Summary
- Rifampin produces rapid and profound reductions in methadone levels, resulting in the development of opioid withdrawal
- Rifabutin should be substituted for rifampin, or methadone doses should be increased rapidly during coadministration[Kreek 1976]
- Fluconazole increases methadone exposure, and methadone dosage may need to be reduced in patients receiving both drugs[Cobb 1998]
Action required
- Login now to access all of your entitled content
or - View additional options to gain access to this content