Special Considerations and Clinical Management of HIV in Patients With Substance Use Disorder
Summary
- Rifampin produces rapid and profound reductions in methadone levels, resulting in the development of opioid withdrawal
- Rifabutin should be substituted for rifampin, or methadone doses should be increased rapidly during coadministration[Kreek 1976]
- Fluconazole increases methadone exposure, and methadone dosage may need to be reduced in patients receiving both drugs[Cobb 1998]
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