Absence of opioid withdrawal symptoms in patients receiving methadone and the protease inhibitor lopinavir-ritonavir.

Clarke S, Mulcahy F, Bergin C, Reynolds H, Boyle N, Barry M, Back DJ.

Clin Infect Dis. 2002 Apr 15;34(8):1143-5. doi: 10.1086/339541. Epub 2002 Mar 19.

A study was designed to determine the interactions, both clinical and pharmacokinetic, between methadone and lopinavir-ritonavir. Results demonstrated a 36% reduction in the methadone area under the plasma concentration-time curve after the introduction of lopinavir-ritonavir, with no coincident symptoms of opioid withdrawal and no requirement for methadone dose adjustment.

PMID: 11915005

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.