inPractice® - Treatment Efficacy in Older vs Younger Patients With HIV

Special Considerations Related to Aging in Persons With HIV

Author: Matthew B. Goetz, MD (More Info)
Section Editor: Judith S. Currier, MD, MSc
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 11/1/21 (What's New)

Summary

Clinical Response to Therapy

Combination ART provides substantial benefit to older patients^{[Bhaskaran 2008b; Porter 2003; Ewings 2008; Davis 2013]}
Risk of AIDS or death after ART initiation remains greater in older vs younger patients, after adjusting for CD4+ cell count, HIV-1 RNA, disease stage, and previous injection drug use (Figure 3)^{[COHERE 2008; Ewings 2008; May 2007; Mussini 2008; Greenbaum 2008]}

Virologic Response to Therapy

Inferior clinical outcomes in older persons with HIV are not explained by poor virologic response to ART

Immunologic Response to Therapy

Timing of Therapy

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Keywords: HIV and Older Patients