Management of Bone Disease and Body Composition Changes

  • Author: Donald P. Kotler, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/7/18 (What's New)


  • Subacute lactic acidosis related to thymidine analogues has been associated with osteopenia[Carr 2001]
    • Chronic metabolic acidosis of any type will cause bone demineralization as a result of buffering
  • Results of epidemiologic studies suggest that PI therapy increases the prevalence of osteopenia[Brown 2006]
    • Effect of ART vs No ART
        Effect of Tenofovir DF
          Effect of Tenofovir AF vs Tenofovir DF
            Effect of Other Regimens
              Other Factors

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