Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Colchicine requires dose adjustments when used with PIs, cobicistat/elvitegravir/emtricitabine/tenofovir DF, or cobicistat/elvitegravir/emtricitabine/tenofovir AF[DHHS ART]
- Colchicine should not be coadministered with cobicistat/elvitegravir/emtricitabine/tenofovir DF or cobicistat/elvitegravir/emtricitabine/tenofovir AF in patients with renal or hepatic impairment[FDA COBI/EVG/TDF/FTC; FDA COBI/EVG/TAF/FTC]
- Dose adjustment of metformin should be considered during coadministration with dolutegravir and total daily metformin dose should not exceed 1000 mg[FDA Dolutegravir]
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Keywords: Drug-Drug Interactions, Pharmacokinetics