Fungal Infections
Summary
- Guidelines from the WHO recommend treatment with amphotericin B and flucytosine followed by fluconazole (Management Guidelines)[WHO 2018; Molloy 2018]
- Widespread use of fluconazole has been associated with the emergence of fluconazole-resistant cryptococcal infection[Parkes-Ratanshi 2011; Bicanic 2006]
- Screening for cryptococcal antigen in patients initiating ART with CD4+ cell counts < 100 cells/mm³ has been found clinically efficacious and may be an alternative to primary prophylaxis[Jarvis 2009; Meya 2010]
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Keywords: Cryptococcus