Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/3/19 (What's New)

Summary

  • Herbal and vitamin supplements may contain polyvalent cations, including aluminum, calcium, iron, magnesium, and zinc ions, which may cause decreases in integrase inhibitor concentrations
  • Separating administration by 2-6 hours is sufficient to avoid decreases in integrase inhibitor concentrations

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Keywords: Drug-Drug Interactions, Pharmacokinetics

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