Management of Bone Disease and Body Composition Changes
Summary
- Ability of DNA polymerase inhibitors to cause mitochondrial dysfunction initially came to attention during clinical studies of a fluorinated uridine developed to treat chronic HBV infection[McKenzie 1995]
- Mitochondrial hypothesis posits that certain NRTIs inhibit mitochondrial DNA polymerase gamma, leading to mitochondrial DNA depletion
- Mitochondrial toxicity has been linked clinically to lipoatrophy, as well as several other conditions[Brinkman 1998; Kakuda 1999]
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Keywords: Fat Perturbations, Mitochondrial Disorders