Management of IRIS
Summary
- Guidelines recommend early ART initiation in patients with OIs (other than cryptococcal meningitis), although development of IRIS is a potential disadvantage of this strategy (Management Guidelines)[CDC OI] (Management Guidelines)[BHIVA ART] ART Initiation and IRIS in Patients With Tuberculosis
- Early ART initiation in patients with TB is associated with increased rates of IRIS[Abdool Karim 2010; Havlir 2011; Luetkemeyer 2014; Blanc 2011]
- However, early ART initiation in severely lymphopenic patients is also associated with reduced mortality[Abdool Karim 2010; Havlir 2011; Luetkemeyer 2014; Blanc 2011]
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Keywords: Initial Antiretroviral Therapy, IRIS