inPractice® - Timing of Antiretroviral Therapy

Management of IRIS

Authors: Irini Sereti, MD, MHS; Philip Grant, MD (More Info)
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 4/1/16 (What's New)

Summary

Guidelines recommend early ART initiation in patients with OIs (other than cryptococcal meningitis), although development of IRIS is a potential disadvantage of this strategy (Management Guidelines)^{[CDC OI]}(Management Guidelines)^{[BHIVA ART]}

ART Initiation and IRIS in Patients With Tuberculosis

Early ART initiation in patients with TB is associated with increased rates of IRIS^{[Abdool Karim 2010; Havlir 2011; Luetkemeyer 2014; Blanc 2011]}
However, early ART initiation in severely lymphopenic patients is also associated with reduced mortality^{[Abdool Karim 2010; Havlir 2011; Luetkemeyer 2014; Blanc 2011]}

ART Initiation and IRIS in Patients With Cryptococcosis

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Keywords: Initial Antiretroviral Therapy, IRIS