Metabolic Complications of HIV and Antiretroviral Therapy: Dyslipidemia, Insulin Resistance, and Cardiovascular Disease
Summary
- Metformin is the only agent endorsed by the American Diabetes Association for the prevention of diabetes
- Can be considered for patients with impaired glucose tolerance, impaired fasting glucose, or an A1C of 5.7% to 6.4%, particularly those younger than 60 years of age, those with a BMI ≥ 35, and women with previous gestational diabetes mellitus)[ADA 2013a]
- Metformin has been shown to improve insulin resistance and decrease body weight after 3 months of therapy in small studies in HIV-infected patients, particularly for patients with lipodystrophy and elevated levels of fasting insulin[Hadigan 2000; van Wijk 2005]
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