inPractice® - Oral Anticoagulants

Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
Section Editor: Eric S. Daar, MD
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 6/3/19 (What's New)

Cautious dosing and frequent INR monitoring are required in patients receiving antiretrovirals and warfarin^{[DHHS ART]}
- Despite the need for close INR monitoring, warfarin is compatible with most ARVs
Coadministration of ARVs with novel oral anticoagulants is, for the most part, not recommended due to the potential for significant interactions; instead, DHHS guidelines recommend warfarin or an alternate ARV^{[Rao 2017; FDA Dabigatran; FDA Rivaroxaban; FDA Apixaban; FDA Betrixaban; FDA Edoxaban; DHHS ART]}