Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Cautious dosing and frequent INR monitoring are required in patients receiving antiretrovirals and warfarin[DHHS ART]
- Despite the need for close INR monitoring, warfarin is compatible with most ARVs
- Coadministration of ARVs with novel oral anticoagulants is, for the most part, not recommended due to the potential for significant interactions; instead, DHHS guidelines recommend warfarin or an alternate ARV[Rao 2017; FDA Dabigatran; FDA Rivaroxaban; FDA Apixaban; FDA Betrixaban; FDA Edoxaban; DHHS ART]
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Keywords: Drug-Drug Interactions, Pharmacokinetics