Agents Used in Antiretroviral Therapy

  • Authors: Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 7/19/21 (What's New)


  • Darunavir in combination with other antiretroviral agents is indicated for treatment of HIV infection; it must be coadministered with ritonavir or cobicistat as a boosted PI[FDA Darunavir]
  • Darunavir is active against many PI-resistant HIV variants
  • Darunavir is given orally at a dose of 600 mg with ritonavir 100 mg twice daily for treatment-experienced with darunavir-associated resistance or 800 mg with ritonavir 100 mg once daily for all other patients

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