Management of Bone Disease and Body Composition Changes
Summary
- Hepatic failure with refractory lactic acidosis is the most serious disease complication related to mitochondrial dysfunction, but it is rare
- Lactic acidosis was first recognized to occur as a complication of zidovudine use, although other thymidine NRTIs, such as stavudine and the adenosine NRTI didanosine appear to provide an even higher risk (Management Guidelines)[EACS ART]
- Stavudine and didanosine should not be used in combination[EACS ART]
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Keywords: Hepatic Complications