Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Phenytoin, phenobarbital, and carbamazepine can be increased or decreased when combined with PIs or NNRTIs, respectively[Spina 2002; Liedtke 2004; Lim 2004; Ji 2008]
- Interactions between oxcarbazepine and antiretrovirals are likely[Spina 2002]
- Coadministration of oxcarbazepine and eslicarbazepine with any PI is not recommended, but if necessary, concentrations of both drugs should be monitored[DHHS ART]
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Keywords: Drug-Drug Interactions, Pharmacokinetics