inPractice® - Antiepileptics

Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
Section Editor: Eric S. Daar, MD
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 6/1/18 (What's New)

Summary

Phenytoin, phenobarbital, and carbamazepine can be increased or decreased when combined with PIs or NNRTIs, respectively^{[Spina 2002; Liedtke 2004; Lim 2004; Ji 2008]}
Interactions between oxcarbazepine and antiretrovirals are likely^{[Spina 2002]}
Coadministration of oxcarbazepine and eslicarbazepine with any PI is not recommended, but if necessary, concentrations of both drugs should be monitored^{[DHHS ART]}

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Keywords: Drug-Drug Interactions, Pharmacokinetics