Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Most antipsychotics can be coadministered with antiretrovirals, although careful monitoring is required and dose modification of the antipsychotic may be needed
- Antipsychotic concentrations typically increase with PIs, cobicistat/elvitegravir/emtricitabine/tenofovir DF, and cobicistat/elvitegravir/emtricitabine/tenofovir AF and decrease with NNRTIs[Urichuk 2008; FDA COBI/EVG/TDF/FTC; FDA COBI/EVG/TAF/FTC; DHHS ART] Typical Antipsychotics and Antiretrovirals
- Inhibitors of CYP 2D6, such as ritonavir and cobicistat, should be coadministered with chlorpromazine and thioridazine with extreme caution
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