Guidelines on opportunistic infections from the CDC recommend that prophylaxis should be prescribed for all Toxoplasma-seropositive patients with HIV who have CD4+ cell counts < 100 cells/mm3 (Table 4) (Management Guidelines)[CDC OI]
The European AIDS Clinical Society guideline recommends that prophylaxis should be prescribed for all patients with HIV who have CD4+ cell counts < 200 cells/mm3 or CD4+ percentage < 14% or with oral thrush and relevant immunosuppression (Management Guidelines)[EACS]