Clinical Implications of HIV Pathogenesis

  • Author: David M. Margolis, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/4/18 (What's New)

Summary

  • Initiation of potent ART results in a decay in plasma HIV-1 RNA levels and an increase in CD4+ cell count[Ho 1995; Wei 1995]
    • Initial phase of viral decay reflects elimination of free virus and the turnover of productively infected, activated CD4+ T cells
    • A more gradual phase follows that is thought to reflect clearance of infection in cells that divide less quickly

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