Management of AIDS-Defining Cancers

  • Authors: David Aboulafia, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/9/18 (What's New)


  • PCNSL is a subtype of DLBCL strongly related to Epstein-Barr virus infection and usually occurs in patients with advanced HIV disease (CD4+ cell count < 50 cells/mm3)
  • Cerebrospinal fluid cytology, toxoplasmosis serologic testing, and an empiric trial of antibiotics may be needed to distinguish differential diagnoses such as infections, other tumors, and disease entities (Management Guidelines)[BHIVA HIV Cancer]
  • Bone marrow biopsy, chest and abdomen CT scan, testicular ultrasound, and physical examination to detect occult systemic lymphoma is also recommended[BHIVA HIV Cancer]

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Keywords: Cancer