Management of AIDS-Defining Cancers
Summary
- Trials investigating use of rituximab in patients with AIDS-related lymphomas have reported generally favorable results[Levine 2008; Boué 2006; Spina 2005; Kaplan 2005; Levine 2013a; Ribera 2013; Wyen 2012; Barta 2013; Levine 2013b]
- The BHIVA guidelines recommend the addition of rituximab to chemotherapy in patients with DLBCL and Burkitt’s lymphoma (Management Guidelines)[BHIVA HIV Cancer]
- Patients must be screened for HBV infection prior to initiating rituximab, as immunosuppressant therapy can cause reactivation of HBV[FDA 2013; Tsutsumi 2010]
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Keywords: Cancer, Viral Hepatitis Coinfection