Special Considerations Related to Aging in HIV-Infected Patients

  • Author: Matthew B. Goetz, MD (More Info)
  • Section Editor: Judith S. Currier, MD, MSc
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/28/15 (What's New)

Summary

  • Higher rates of adverse medication effects are observed in older HIV-infected patients vs younger HIV-infected patients[Silverberg 2007; Sabin 2009; Lodwick 2008; Edelman 2013]
  • Increased age is associated with decreased functioning of the hepatic cytochrome P450 enzyme system and decreased renal tubular secretion and glomerular filtration[Sotaniemi 1997; Schwartz 2007; Ramsay 1981]
  • Age-related changes in body composition also influence drug pharmacokinetics

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