Special Considerations Related to Aging in Persons With HIV
Summary
- Higher rates of adverse medication effects are observed in older vs younger patients with HIV[Silverberg 2007; Sabin 2009; Lodwick 2008; Edelman 2013]
- Increased age is associated with decreased functioning of the hepatic cytochrome P450 enzyme system and decreased renal tubular secretion and glomerular filtration[Sotaniemi 1997; Schwartz 2007; Ramsay 1981]
- Age-related changes in body composition also influence drug pharmacokinetics
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Keywords: HIV and Older Patients