Special Considerations Related to Aging in HIV-Infected Patients

  • Author: Matthew B. Goetz, MD (More Info)
  • Section Editor: Judith S. Currier, MD, MSc
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/28/15 (What's New)

Summary

  • Higher rates of adverse medication effects are observed in older HIV-infected patients vs younger HIV-infected patients[Silverberg 2007; Sabin 2009; Lodwick 2008; Edelman 2013]
  • Increased age is associated with decreased functioning of the hepatic cytochrome P450 enzyme system and decreased renal tubular secretion and glomerular filtration[Sotaniemi 1997; Schwartz 2007; Ramsay 1981]
  • Age-related changes in body composition also influence drug pharmacokinetics

Action required

Keywords: HIV and Older Patients

©2018 Clinical Care Options, LLC. All Rights Reserved.

The materials published via inPractice® reflect the views of the reviewers or authors of the material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.