Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Effect of paroxetine on ritonavir-boosted PIs may be unpredictable[van der Lee 2007]
- Concentrations of bupropion are decreased, or may be decreased, when combined with lopinavir/ritonavir, tipranavir/ritonavir, atazanavir/ritonavir, darunavir/ritonavir, nevirapine, or efavirenz with dose titration being recommended[Hogeland 2007; DHHS ART]
- TCAs interact with all PIs, cobicistat/elvitegravir/emtricitabine/tenofovir DF, and cobicistat/elvitegravir/emtricitabine/tenofovir AF and, therefore, should be started at the lowest possible dose and titrated[DHHS ART; FDA COBI/EVG/TDF/FTC; FDA COBI/EVG/TAF/FTC]
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