Agents Used in Antiretroviral Therapy

  • Authors: Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 7/19/21 (What's New)

Summary

  • Nevirapine is an NNRTI indicated in combination with other antiretroviral agents
  • It can be administered to treatment-naive and treatment-experienced patients, but caution should be employed when initiating nevirapine-based antiretroviral therapy in women with CD4+ cell counts > 250 cells/mm3 or men with CD4+ cell counts > 400 cells/mm3
  • Nevirapine should be administered initially at 200 mg once daily (immediate-release formulation) for 14 days; if well tolerated, full dose is 200 mg twice daily (immediate-release) or 400 mg once daily (extended-release)[FDA Nevirapine XR]

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    Keywords: Hepatic Complications, Initial Antiretroviral Therapy, Management of Treatment-Experienced Patients, Resource-Limited Settings, Special Populations, Treatment Complications

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