Timing of Initiation of First-line Antiretroviral Therapy
Summary
- Data suggest that uncontrolled HIV replication and advanced HIV disease may contribute to atherosclerosis
- In the SMART study, there were more coronary heart disease events in patients receiving intermittent ART vs patients receiving continuous therapy[SMART 2006]
- Potential mechanisms include increased inflammation or worsened lipid profile during treatment interruption[Phillips 2008; Kuller 2008]
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