Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Active metabolite of clopidogrel may be decreased when coadministered with etravirine; avoid coadministration if possible (Table 6)[FDA Etravirine; DHHS ART]
- There is also potential for clopidogrel inactivation by efavirenz[Hughes 2015; Xu 2013]
- Prasugrel can be coadministered with CYP 3A4 inhibitors and inducers, as well as with CYP 2B6 substrates such as nevirapine[FDA Prasugrel]
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Keywords: Drug-Drug Interactions, Pharmacokinetics