inPractice® - Platelet Aggregation Inhibitors

Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
Section Editor: Eric S. Daar, MD
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 6/1/18 (What's New)

Summary

Active metabolite of clopidogrel may be decreased when coadministered with etravirine; alternative combinations should be considered (Table 6)^{[FDA Etravirine; DHHS ART]}
- There is also potential for clopidogrel inactivation by efavirenz^{[Hughes 2015; Xu 2013]}; thus their coadministration should be avoided
- Coadministration with nevirapine and rilpivirine does not require dose adjustments

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Keywords: Drug-Drug Interactions, Pharmacokinetics