Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Interactions between antiretrovirals and herbal and dietary supplements are often difficult to predict
- Potential for decreased activity of antiretrovirals with garlic supplements, St. John’s wort, and ascorbic acid (vitamin C)[Piscitelli 2000; Piscitelli 2002; Slain 2005]
- Coadministration of St. John’s wort and garlic supplements with any antiretroviral that is metabolized by CYP 450 enzymes or a substrate of P-gp is contraindicated[DHHS ART; Fasinu 2015; Stolbach 2015] Polyvalent Cations
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Keywords: Drug-Drug Interactions, Pharmacokinetics