Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Acid Suppression Agents
- Acid suppression agents can interact with antiretrovirals, which may influence regimen selection in patients receiving these drugs concomitantly (Table 3)
- Several antiretrovirals have critical interactions with these drugs; clinicians should ask patients specifically about use of over-the-counter medications; dosing adjustments may be needed Antiretrovirals and Antacids
- Caution should be advised when antacids are used with atazanavir (with or without ritonavir), fosamprenavir, or tipranavir/ritonavir
- PIs and Statins
- Fluconazole and NNRTIs and PIs
- Rifampin and Antiretrovirals
- Typical Antipsychotics and Antiretrovirals
- Polyvalent Cations
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Keywords: Drug-Drug Interactions, Pharmacokinetics