Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/1/18 (What's New)

Summary

    Acid Suppression Agents
    • Acid suppression agents can interact with antiretrovirals, which may influence regimen selection in patients receiving these drugs concomitantly (Table 3)
    • Several antiretrovirals have critical interactions with these drugs; clinicians should ask patients specifically about use of over-the-counter medications; dosing adjustments may be needed
    • Antiretrovirals and AntacidsAtazanavir and Acid-Reducing Agents
        Fosamprenavir and Acid-Reducing Agents
          Other PIs and Acid-Reducing Agents
            Rilpivirine and Acid-Reducing Agents
            HMG Co-A Reductase Inhibitors
              PIs and Statins
                NNRTIs and Statins
                  Integrase Inhibitors, Other ARVs, and Statins
                  Phosphodiesterase Inhibitors
                    Therapies for Pulmonary Arterial Hypertension
                      Antifungals
                        Fluconazole and NNRTIs and PIs
                          Isavuconazole and NNRTIs and PIs
                            Itraconazole and NNRTIs and PIs
                              Posaconazole and NNRTIs and PIs
                                Voriconazole and NNRTIs and PIs
                                  Ketoconazole and NNRTIs and PIs
                                    Azole Antifungals and Other Antiretrovirals
                                    Asthma Medications
                                      Platelet Aggregation Inhibitors
                                        Antiarrhythmics
                                          Calcium Channel Blockers and Other Cardiac Medications
                                            Beta-blockers
                                              Alpha-blockers
                                                Antimycobacterials
                                                  Rifampin and Antiretrovirals
                                                    Rifabutin and Antiretrovirals
                                                      Rifapentine and Antiretrovirals
                                                        Other Antimycobacterial Agents and Antiretrovirals
                                                        Oral Anticoagulants
                                                          Corticosteroids
                                                            Benzodiazepines
                                                              Antipsychotics
                                                                Typical Antipsychotics and Antiretrovirals
                                                                  Atypical Antipsychotics and Antiretrovirals
                                                                  Antidepressants
                                                                    Antiepileptics
                                                                      Immunosuppressants
                                                                        Sedatives/Hypnotics
                                                                          Antivirals
                                                                            Hormonal Contraceptives
                                                                              Opioid Substitution Therapy
                                                                                Herbal and Dietary Supplements
                                                                                  Polyvalent Cations
                                                                                  Vasoconstrictors
                                                                                    Miscellaneous Interactions

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