Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Most antiretrovirals are metabolized via the liver and are known as substrates for liver enzyme metabolism
- Raltegravir and dolutegravir are primarily metabolized by glucuronidation via the UGT1A1 enzyme[FDA Raltegravir; Reese 2013]
- Raltegravir is available in 2 doses for treatment-naive patients and patients who are virologically suppressed on an initial 400-mg twice-daily regimen: 400 mg twice daily or 1200 mg once daily[FDA Raltegravir]
- Raltegravir and dolutegravir are primarily metabolized by glucuronidation via the UGT1A1 enzyme[FDA Raltegravir; Reese 2013]
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Keywords: Drug-Drug Interactions, Pharmacokinetics