Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/12/21 (What's New)


  • 2 boosted PIs are currently included among choices for first-line therapy in US and European guidelines
  • Atazanavir is included as an alternative option in the DHHS and EACS guidelines[DHHS ART; EACS ART]
  • Darunavir is included as an alternative option in the DHHS, IAS-USA, and EACS guidelines[DHHS ART; IASUSA ART; EACS ART]
  • Boosted Atazanavir-Based Initial Therapy
      Atazanavir + Ritonavir Initial Therapy
        Atazanavir/Cobicistat-Based Initial Therapy
        Boosted Darunavir-Based Initial Therapy
          Darunavir/Ritonavir Initial Therapy
            Darunavir/Cobicistat-Based Initial Therapy

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