Guidelines on opportunistic infections recommend persons with HIV and epidemiologic risk factors for Chagas disease should be serologically tested to detect latent infection (Management Guidelines)[CDC OI]
Antibody-positive patients who are likely to have been infected for < 2 decades, without signs or symptoms of Chagas disease, and who have not been previously treated, may benefit from a single course of benznidazole or nifurtimox (Table 10) (Management Guidelines)[CDC OI] (Management Guidelines)[GESIDA OI]
Reactivation of Chagas disease may be prevented by optimization of ART
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