Key Principles and Recommended Regimens for First-line Antiretroviral Therapy
Summary
- The ARTEMIS study compared darunavir + ritonavir with lopinavir/ritonavir, both combined with emtricitabine/tenofovir DF in 689 treatment-naive patients[Ortiz 2008]
- At Week 48, the virologic efficacy of darunavir + ritonavir was noninferior to that of lopinavir/ritonavir; the proportion of patients achieving HIV-1 RNA < 50 copies/mL was 84% on darunavir + ritonavir and 78% on lopinavir/ritonavir (P < .001)
- Superiority of darunavir + ritonavir in the overall population seen at Week 96[Mills 2009]
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Keywords: Initial Antiretroviral Therapy