Laboratory Assays in the Clinical Management of Antiretroviral Therapy

  • Author: Mark Holodniy, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 12/12/17 (What's New)


  • Current guidelines recommend genotypic resistance testing for all HIV-infected persons at entry into care regardless of whether antiretroviral therapy will be initiated (Management Guidelines)[DHHS ART]
  • If antiretroviral therapy is deferred, repeat resistance testing should be considered at the time of treatment initiation, particularly in patients at risk of transmission of drug-resistant virus
  • If transmitted resistance to integrase inhibitors is suspected, providers may opt to supplement standard testing with an integrase inhibitor genotypic resistance test 

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