Management of IRIS

  • Authors: Irini Sereti, MD, MHS; Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • Cryptococcal IRIS commonly presents with CNS findings but can also present with pulmonary disease and/or lymphadenitis
  • Presentation can be substantially delayed after ART initiation, reportedly up to 2 years[Lortholary 2005; Jenny-Avital 2002; Sungkanuparph 2007]
  • INSHI has established consensus definitions for unmasking and paradoxical cryptococcal IRIS[Haddow 2010]

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