Management of IRIS

  • Authors: Irini Sereti, MD, MHS; Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)

Summary

  • Cryptococcal IRIS commonly presents with CNS findings but can also present with pulmonary disease and/or lymphadenitis
  • Presentation can be substantially delayed after ART initiation, reportedly up to 2 years[Lortholary 2005; Jenny-Avital 2002; Sungkanuparph 2007]
  • INSHI has established consensus definitions for unmasking and paradoxical cryptococcal IRIS[Haddow 2010]

Action required

Keywords: Cryptococcus, IRIS

©2020 Clinical Care Options, LLC. All Rights Reserved.

The materials published via inPractice® reflect the views of the reviewers or authors of the material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.