Management of Hematologic Disorders

  • Author: David Aboulafia, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)

Summary

  • TTP is associated with early and late HIV with associated mortality of 50% to 80% without treatment but less than 10% if recognized and treated early
    • Manifests clinically as multisystem disease with thrombocytopenia, hemolytic anemia, renal impairment, fever, and neurologic abnormalities (agitation, disorientation, headache early, late focal deficits, seizure, coma)
  • Platelet transfusion may lead to new or worsening neurologic and renal complications and not generally recommended in TTP[Bell 1991]

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