inPractice® - Thrombotic Thrombocytopenic Purpura

TTP is associated with early and late HIV with associated mortality of 50% to 80% without treatment but less than 10% if recognized and treated early
- Manifests clinically as multisystem disease with thrombocytopenia, hemolytic anemia, renal impairment, fever, and neurologic abnormalities (agitation, disorientation, headache early, late focal deficits, seizure, coma)
Platelet transfusion may lead to new or worsening neurologic and renal complications and not generally recommended in TTP^{[Bell 1991]}