Non–AIDS-Defining Cancers

  • Authors: David Aboulafia, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/15/21 (What's New)


  • Primary care physicians should promote behavioral modifications (eg, safe sexual practices, smoking cessation, avoiding extreme sun exposure, and aggressive use of sunscreen) and implement regular screening for non-AIDS malignancies in persons with HIV (Table 2)
  • Periodic health assessments should include an examination for cancers such as those of the head and neck (including the oropharynx), lymph nodes, testicles, and skin
  • Risk factors for NADCs in persons with HIV include low CD4+ cell counts, older age, family history of cancer, exposure to carcinogens

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