Special Considerations and Clinical Management of HIV-Infected Drug Users
Summary
- Most PIs do not appear to have clinically meaningful effects on methadone levels (Table 8)[Bruce 2006a; Sekar 2010]
- Clinically significant interactions between buprenorphine and atazanavir/ritonavir and tipranavir/ritonavir have been reported[Friedland 2005; McCance-Katz 2007; Bruce 2009b]
- Dose adjustments are unlikely to be needed when coadministering buprenorphine with darunavir/ritonavir, fosamprenavir/ritonavir,[Gruber 2012] lopinavir/ritonavir, nelfinavir, or ritonavir[McCance-Katz 2006b] Lopinavir/Ritonavir
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