Clinical Implications of HIV Pathogenesis

  • Author: David M. Margolis, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 9/4/18 (What's New)


  • Treatment guidelines now recommend initiation of ART as soon as possible following HIV diagnosis in patients willing to commit to lifelong therapy (Management Guidelines)[DHHS ART]
  • Much of the damage to the immune system and other cell systems caused by HIV may occur in the first few weeks following acute HIV infection and may or may not be reversible with immune restoration
  • In addition to receiving ART, clinically stable HIV-infected patients should receive assiduous general preventive medical care, including screening tests for end-organ disease (Management Guidelines)[Primary Care 2013]

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