Management of IRIS

  • Authors: Irini Sereti, MD, MHS; Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • Diagnosis and treatment of patients with IRIS should be managed by a specialist
  • Primary care providers should be aware that patients with low baseline CD4+ cell counts with a robust response to ART are at increased risk of IRIS
  • ART should not be delayed in patients for whom it is indicated, although guidance for patients with cryptococcal disease is evolving

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