Guidelines on opportunistic infections indicate that benznidazole and nifurtimox are useful for reducing parasitemia and preventing clinical manifestations in congenital, acute phases and reactivations of Chagas disease (Table 11) (Management Guidelines)[CDC OI](Management Guidelines)[Panel 2008b]
Neither antitrypanosomal drug is licensed in the United States, but they are available from the CDC Drug Service for use under investigational protocols
Optimal duration of therapy has not been established in HIV-infected patients
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