Special Considerations and Clinical Management of HIV in Patients With Substance Use Disorder
Summary
- Drug interactions between opioid substitution therapy and antiretroviral medications may result in increased toxicity or reduced efficacy of ART or in clinical opioid withdrawal or overdose NRTIs
- Currently approved NRTIs do not precipitate opioid withdrawal
- Methadone affects the pharmacokinetics of several NRTIs (Table 6),[Bruce 2006a; Bruce 2013a] including zidovudine[Rainey 2002] and stavudine[Rainey 2000]
- Lopinavir/Ritonavir
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