Agents Used in Antiretroviral Therapy

  • Authors: Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/9/19 (What's New)

Summary

  • Maraviroc, in combination with other antiretroviral agents, is indicated for adult patients infected with CCR5-tropic HIV only[FDA Maraviroc]
  • Maraviroc is a substrate for cytochrome P450 3A4 and dosed according to other agents in regimen (Table 17)[FDA Maraviroc]
  • In clinical trials, maraviroc-containing regimens have been associated with greater CD4+ cell count increases than comparator regimens, but clinical implications of this finding have not been elucidated

Action required

Keywords: Drug-Drug Interactions, Initial Antiretroviral Therapy, Management of Treatment-Experienced Patients, Special Populations, Treatment Complications, Tropism

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