Management of Bone Disease and Body Composition Changes

  • Author: Donald P. Kotler, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 5/7/18 (What's New)

Summary

  • Rationale for using human growth hormone is the known inverse relationship between visceral adipose tissue and secretion of human growth hormone[Veldhuis 1995]
    • Overnight secretion of human growth hormone has also been found to be reduced in HIV-infected men with lipodystrophy compared with controls and HIV-infected subjects without lipodystrophy[Rietschel 2001]
  • Low-dose somatropin (1 mg/day) (recombinant human growth hormone) therapy has been found to reduce visceral adipose tissue but worsen insulin resistance in nonHIV-infected men with central obesity[Johannsson 1997; Lo 2008]

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