Modifying Antiretroviral Therapy in Virologically Suppressed HIV-Infected Patients
Summary
- Only 10% of virologically suppressed patients receiving lopinavir/ritonavir plus 2 NRTIs switched to lopinavir/ritonavir monotherapy experienced viral rebound if they had been virologically suppressed for ≥ 6 months before switching[Bierman 2009]
- Patients experiencing virologic rebound were able to reattain virologic suppression with the reintroduction of NRTIs[Bierman 2009; Mathis 2011]
- Virologic rebound almost exclusively occurs in the absence of emergent PI resistance mutations[McKinnon 2011]
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Keywords: Adherence, Fat Perturbations, Switch Strategies