Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- HMG Co-A reductase inhibitors, or statins, interact with both PIs and NNRTIs (Table 4)
- PIs generally inhibit CYP 3A4 and P-gp, resulting in increased statin exposure during coadministration[Holtzman 2006]
- NNRTIs generally decrease statin concentrations, necessitating higher statin doses for efficacy
PIs and Statins
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Keywords: Drug-Drug Interactions, Pharmacokinetics