Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/1/18 (What's New)

Summary

  • HMG Co-A reductase inhibitors, or statins, interact with both PIs and NNRTIs (Table 4)
    • PIs generally inhibit CYP 3A4 and P-gp, resulting in increased statin exposure during coadministration[Holtzman 2006]
    • NNRTIs generally decrease statin concentrations, necessitating higher statin doses for efficacy
    • PIs and Statins
      NNRTIs and Statins
        Integrase Inhibitors, Other ARVs, and Statins

        Action required

        Keywords: Drug-Drug Interactions, Pharmacokinetics

        ©2018 Clinical Care Options, LLC. All Rights Reserved.

        The materials published via inPractice® reflect the views of the reviewers or authors of the material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.