Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/3/19 (What's New)

Summary

  • HMG Co-A reductase inhibitors, or statins, interact with both PIs and NNRTIs (Table 4)
    • PIs generally inhibit CYP 3A4 and P-gp, resulting in increased statin exposure during coadministration[Holtzman 2006]
    • NNRTIs generally decrease statin concentrations, necessitating higher statin doses for efficacy
    • PIs and Statins
      NNRTIs and Statins
        Integrase Inhibitors, Other ARVs, and Statins

        Action required

        Keywords: Drug-Drug Interactions, Pharmacokinetics

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