Management of Children With or Exposed to HIV

  • Authors: James A. McAuley, MD, MPH; Mariam Aziz, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 9/5/21 (What's New)


  • Incidence of opportunistic infections in children with HIV has decreased with the availability of effective ART[Gona 2006; Nesheim 2007]
  • PCP prophylaxis indicated in all infants younger than 12 months of age and children with severe immune suppression (aged 1 to younger than 6 years with a CD4+ cell count < 500 cells/mm3 or percentage < 15% or 6 years of age or older with CD4+ cell count < 200 cells/mm3 or percentage < 15%), preferably with sulfamethoxazole/trimethoprim[DHHS OI HIV Pediatric]
  • Mycobacterium avium complex prophylaxis with weekly azithromycin or clarithromycin is recommended for children based on their age and CD4+ cell count[DHHS OI HIV Pediatric]

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