Management of AIDS-Defining Cancers

  • Authors: David Aboulafia, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/9/18 (What's New)


  • Patients may present with minimal disease or with rapidly progressive KS, which is associated with substantial morbidity and mortality[Dezube 2000]
  • KS exacerbation can result from IRIS following ART initiation, after corticosteroid use, or with rituximab therapy[Leidner 2005; Pantanowitz 2008]
  • Risk factors for KS-IRIS include HIV-1 RNA > 105 copies/mL, detectable plasma HHV-8 DNA, ART as initial KS treatment, and stage T1 KS[Letang 2013]

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