Laboratory Assays in the Clinical Management of Antiretroviral Therapy

  • Author: Mark Holodniy, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 12/12/17 (What's New)

Summary

  • The AIDS Clinical Trials Group and the DHHS guidelines define virologic failure as confirmed viral load > 200 copies/mL while receiving antiretroviral therapy
  • Any rebound in viral load from undetectable level should be confirmed with repeat testing
  • Persistent low-level viremia, even at levels < 200 copies/mL, may lead to selection of resistance mutations[Li 2012; Taiwo 2011]

Action required