Metabolic Complications of HIV and Antiretroviral Therapy: Dyslipidemia, Insulin Resistance, and Cardiovascular Disease
Summary
- Statins are the preferred treatment for patients with elevated TC and LDL, but individual LDL response to statin dosing varies widely[Willrich 2009]
- Statins may have a modest effect on lowering triglycerides and may also produce mild elevations in HDL[Martínez 2008]
- Statins, PIs, NNRTIs, and elvitegravir are metabolized via CYP450 3A4 enzymes (Table 5)[DHHS ART; FDA 2012; Gerber 2005; FDA Etravirine; FDA COBI/EVG/FTC/TDF; FDA COBI/EVG/FTC/TAF; HIV InSite Statin]
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