Management of Neurologic Diseases

  • Authors: David M. Simpson, MD; Jessica Robinson-Papp, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • DSP is the most common neurologic complication of HIV, affecting > 50% of patients with advanced HIV infection[Morgello 2004]
  • Risk factors for DSP include advancing age; history of stavudine, didanosine, or [drug: zalcitabine] treatment; current ART use; lower CD4+ cell counts; type 2 diabetes; elevated serum triglycerides; and substance misuse[Ellis 2010; Ances 2009; Robinson-Papp 2012]
  • Typical symptoms of HIV-associated DSP are symmetrical numbness, tightness, pain, burning, or hyperalgesia in the feet, without clinically significant weakness[Robinson-Papp 2010]

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