Management of Treatment-Experienced Patients With HIV

  • Author: Eric S. Daar, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 7/13/21 (What's New)


  • Drug selection must rely on understanding drug–drug and drug–food interactions, convenience, tolerability, clinician’s experience, and goal of preserving treatment options
  • Resistance testing of limited use in patients off treatment for some time; clinicians must decide if 2 or 3 fully active drugs can be reliably identified
    • In absence of medical records, may be ideal to use drugs in newer classes (and not previously received by patient) in combination with NRTIs, an NNRTI, and/or a boosted PI

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