inPractice® - Etiology

Risks include higher HIV-1 RNA, lower educational level, older age, anemia, illicit drug use, metabolic syndrome, HBV or HCV coinfection, and female sex
- Before widespread use of ART, severity of neurologic deficit directly correlated with a high cerebral spinal fluid–to–serum ratio of HIV-1 RNA^{[McArthur 1997]}
- In the post-ART era, mild neurocognitive disorder and depression are more accurate predictors of the severity of HAD^{[Stern 2001; Dunlop 2002]}